What Causes Gallbladder Cancer?
Q:
What are the causes of gallbladder cancer?
A:
From studies, we can know several risk factors that lead to gallbladder cancer
Chronic gallbladder inflammation is one of the common causes. If a person has gallstones, the gallbladder will release bile more slowly, which indicates that cells in the gallbladder are exposed to the chemicals in bile for longer. And it can cause irritation and inflammation.
Gene mutations is another cause of gallbladder cancer. It is often acquired during life rather than being inherited. Researchers have found that acquired changes in the TP53 tumor suppressor gene could play a role in gallbladder cancer. The mutation of genes such as KRAS, BRAF, CDKN2, and HER2 may also cause this disease.
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