What Is Corticobasal Degeneration?

What is corticobasal degeneration?

Corticobasal degeneration (CBD) is a progressive neuro-degenerative disease characterized by asymmetrical parkinsonism and cognitive dysfunction.


It seems that the etiology of CBD is still unknown at this point, but studies indicate that it is caused by a build-up of a protein called tau that may damage brain cells in certain parts of the brain.


Symptoms of CBD usually affect one side of the body at first, but eventually affect both sides as the disease progresses over time, which are similar to the signs found in people with Parkinson disease, such as:

  • Poor coordination
  • Akinesia, an inability or difficulty in making voluntary movements
  • Tightening and stiffening of the muscles
  • Limb dystonia
  • Slight tremors during times of activity or muscle tension
  • Involuntary muscle spasms

Patients with CBD eventually become unable to walk.


Unfortunately, there is no standard treatment for CBD, but there are many things that can be done to help manage and relief the symptoms. Treatments provided by care professionals may include:

  • Medication;
  • Physiotherapy;
  • Occupational therapy;
  • Speech and language therapy.

If have any further questions, please contact your doctor.

Key words: Corticobasal degeneration (CBD); asymmetrical parkinsonism; cognitive dysfunction.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.