What is Endometrial Hyperplasia Cancer?


What is endometrial hyperplasia? 


Endometrial hyperplasia is a condition of excessive proliferation of the cells of the endometrium, or inner lining of the uterus. Most cases of endometrial hyperplasia result from high levels of estrogens, combined with insufficient levels of the progesterone-like hormones which ordinarily counteract estrogen’s proliferative effects on this tissue. It may occur in a number of settings, including obesity, polycystic ovary syndrome, estrogen producing tumors and certain formulations of estrogen replacement therapy. Endometrial hyperplasia is a significant risk factor for the development or even co-existence of endometrial cancer, so careful monitoring and treatment of women with this disorder is essential.


What is the difference between endometrial hyperplasia and other hyperplasia?


Like other hyperplastic disorders, endometrial hyperplasia initially represents a physiological response of endometrial tissue to the growth-promoting actions of estrogen.

Endometrial hyperplasia, no matter simple or complex, may develop to endometrial cancer eventually. In one study, about 1.6% of patients diagnosed with these abnormalities developed endometrial cancer. On the other hand, atypical endometrial hyperplasia includes worrisome changes in gland cells, including cell stratification, tufting, loss of nuclear polarity, but atypical endometrial hyperplasia does not show invasion into the connective tissues, the defining characteristic of cancer. Studies found that 22% of patients with atypical hyperplasia eventually developed cancer.


Keywords: endometrial hyperplasia cancer



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* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.