What Is Hyperchloremic Acidosis?

Hyperchloremic acidosis, or hyperchloremic metabolic acidosis, occurs when a loss of bicarbonate (alkali) tips the pH balance in your blood toward becoming too acidic (metabolic acidosis). In response, your body holds onto chloride, causing hyperchloremia. In hyperchloremic acidosis, either your body is losing too much base or retaining too much acid.

A base called sodium bicarbonate helps to keep your blood at a neutral pH. A loss of sodium bicarbonate may be caused by:
severe diarrhea
chronic laxative use
proximal renal tubular acidosis, which is failure of the kidneys to reabsorb bicarbonate from urine
long-term use of carbonic anhydrase inhibitors to treat glaucoma, such as acetazolamide
kidney damage

The potential causes of too much acid being introduced to your blood include: accidental ingestion of ammonium chloride, hydrochloric acid, or other acidifying salts (sometimes found in solutions used for intravenous feeding); certain types of renal tubular acidoses; intake of too much saline solution in the hospital.

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.