What Is Leptomeningeal Disease?

What is leptomeningeal disease?

Leptomeningeal disease (LMD) is also known as carcinomatous meningitis. It occurs when a metastatic or primary disease spreads to the space that stores cerebrospinal fluid. LMD is believed to develop in 3-5% of cancer patients.


  • Headache
  • Seizure
  • Nausea
  • Difficulty walking

As tumor cells get into a person’s cerebrospinal fluid pathways, reach the brain and spinal cord and start to grow, LMD occurs.

So far, the disease is usually treated with chemotherapy.


Keywords: leptomeningeal disease; leptomeningeal metastases

* The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.