What Is Mantle Cell Lymphoma?


What is mantle cell lymphoma?


Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin’s lymphoma (NHL), accounting for about 6% of all NHL cases.

The disease is caused by malignant B lymphocytes in the mantle zone which refers to the outer edge of a lymph node follicle. The growth of the malignant B lymphocytes usually go out of control. Therefore, the number of lymphoma cells accumulates and lymph nodes enlarge. When the lymph nodes grow to a certain size or in other parts of the body, tumors are developed. The cells of MCL can travel through the lymphatic system and the blood to other lymph nodes or tissues, including bone marrow and liver.

MCL is distinguished by overexpression of cyclin D1 that can stimulate the growth of cells in almost all cases. It is usually caused by a rearrangement between chromosomes 11 and 14.


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