What Is the Etiology of RHD?


There are still many young females developing RHD. What is the etiology of RHD?


Rheumatic heart disease (RHD) results from one single severe or recurrent rheumatic fever. Rheumatic fever is a complication of pharyngitis and is inflammatory and nonsuppurative. Pharyngitis is the result of group A-hemolytic streptococci.

In addition, the development and severity of RHD is also related with decreased levels of regulatory T cells which triggers an autoimmune reaction releasing inflammatory cytokines. Others argue that increased spiraling of the umbilical cord can also increase the risk of developing RHD.

According to the familial studies, a vulnerable population has greater risk of developing RHD. It has been found that the development of rheumatic fever and human leukocyte antigen (HLA)-DR subtypes are related.


Keywords: etiology rheumatic heart disease; rheumatic heart disease etiology; rheumatic heart disease caused



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