What Is the Pathogenesis of RHD?


What is the pathogenesis of RHD?


The exact pathogenesis of RHD is still fully understood because of its complexity. It is universally believed that the pathogenesis is related to molecular mimicry between streptococcal antigens and human proteins which lead to autoimmune reactions.

Recently, alterations in various subsets of T cells, Th1, Th2, Th17, and Treg cells, have always been heatedly discussed, which is said to be imperative in the pathogenesis of RHD. What’s more, signature cytokines of these various T cell subsets is also supposed to be associated with pathogenesis of RHD.


Keywords: pathogenesis rheumatic heart disease


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