What Should We Know about GAD65 Test?

Q:
What should we know about GAD65 test?

A:
Before introducing GAD65 test, I want to introduce GAD antibodies test. A Glutamic Acid Decarboxylase Autoantibodies test plays a very important role in detecting type 1 diabetes and latent autoimmune diabetes of adulthood.

Glutamic acid decarboxylase presents in highest concentration in brain and pancreatic beta cells. Antibodies 65 kDa, a form of GAD, comprise the majority of pancreatic islet cell autoantibodies.

People with autoantibodies to GAD65 are at greater risk of developing type 1 diabetes than people without these antibodies. So GAD65 test is usually used for detecting type1 diabetes mellitus, distinguishing between type 1 and type 2 diabetes mellitus, confirming stiff-man syndrome.

Patients with type 1 diabetes usually have antibody levels between 0.03 and 20 nmol/L. Higher than 20nmol/L indicate stiff-man syndrome, acquired cerebellar ataxia, etc.

Keywords: GAD65 test; GAD test

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